Lesion size is a major determinant of the mammographic features of ductal carcinoma in situ: findings from the Sloane project

Lesion size is a major determinant of the mammographic features of ductal carcinoma in situ: findings from the Sloane project
A. Evans, K. Clements, A. Maxwell, H. Bishop, A. Hanby, G. Lawrence, S.E. Pinder
Clinical Radiology 2010 65;3:181-184

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Lesion size has a strong influence on the radiological features of calcific DCIS; small, high-grade lesions often show no casting calcifications, whereas casting calcifications are seen in nearly half of large, low-grade lesions. As small clusters of punctate or granular calcifications may represent high-grade DCIS, an aggressive clinical approach to the diagnosis of such lesions is recommended as the adequate treatment of high-grade DCIS will prevent the occurrence of potentially life-threatening high-grade invasive disease

The mammographic correlations of a new immunohistochemical classification of invasive breast cancer

The mammographic correlations of a new immunohistochemical classification of invasive breast cancer
Clinical Radiology, 2008, 63; 11: 1228-1235

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The mammographic features of breast cancer show significant correlation with molecular classes of invasive breast cancer identified by protein expression IHC analysis. The biological reasons for the findings and implications of these regarding imaging protocols require further study and may provide mechanisms for improvement of detection of these lesions

Radiological appearances of papillary breast lesions

Radiological appearances of papillary breast lesions
M.J. Brookes and A.G. Bourke
Clinical Radiology 2008 63; 11:1265-1273

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The commonest mammographic appearance of a papillary tumour is as a soft-tissue mass, with calcification present in less than half of cases. When calcification is present the pattern is variable, but clusters of pleomorphic calcification can occur, sometimes resembling the mammographic appearance of invasive ductal carcinoma. Ultrasonography of papillary lesions typically shows a solid, oval, intraductal mass, often associated with duct dilatation. A cystic component is also commonly seen, and lesions may appear hypervascular on colour Doppler ultrasound. Magnetic resonance imaging (MRI) has a high sensitivity, but low specificity for detecting papillary tumours, and is useful in establishing the extent and distribution of lesions in patients with multiple papillomatosis. Despite a benign histology on core biopsy, an argument exists for complete surgical excision of all papillary tumours, as a significant proportion of papillomas will contain foci of atypia or overt malignant change